Abstract: The polymorphism of human red cell glyoxalase I was studied inHan subpopulationsfrom six cities by agarose gel electrophoresis. The frequency of GLOI*1 gene and the numberof testes in each subpopulation are as follows: Zhengzhou 0. 1023(220), Harbin 0. 1103(195),Huhhot 0. 1259(210), Guiyang 0. 1373(204), Lanzhou 0.1476(210) and Xi'an 0.1508(199). Asignificant difference of frequencies of GLO I gene was found between the Zhengzhou andLanzhou Han subpopulations. The difference of gene frequencies between Han subpopulationsis evidently smaller than that between ethnic groups in China.

Key words: Han; Glyoxalase; Genetic polymorphism