Abstract: This paper presents a review of the distribution of 49 cases Hb G Co-ushatta in population in the Northwest of China. The incidence of Hb G Coushatta in Xinjiang and Gansu are 0.57‰ and 0.43‰, respectively, and higher than 0.07‰ in Shaanxi. The incidence in the Uygur, Kazak, Khalkhas and Hui are 0.66‰一1.74‰, which are higher than 0.45‰ in Han nationality. The gene flow of Hb G Coushatta seems to direct from North to South and West in China. Concerning the movements of various populations in this area as reported in historical documents, the data suggest that this variant likely originated in the Northeast of Asia and was an important genetic marker of ancient nomadic ethnic groups.

Key words: Hb G Coushatta; Abnormal hemoglobin; Han; Uygur; Kazak; Khalkhas; Hui