Abstract: The genetic polymorphism of red cell acid phosphatase ( AcP) , Esterase D ( EsD) and 6- Phosphogluconate dehydrogenase ( 6- PGD) in nine Ha n subpopulations of China w as studied by starch gel electrophoresis. The results show ed that the gene frequencies o f AcPB1 in Han subpopalations from Lanzhou, Huhhot, Harbin, Xi 'a n, Zheng zhou, Cheng du, Guiyang , Zhang zhou and Meixian W ere 0. 7929, 0. 8167, 0. 7938, 0. 8131, 0. 8088, 0. 8005, 0. 7896, 0. 7794 and 0. 7675; EsD1 gene frequencies w ere o. 6473, 0. 6148, 0. 6443, 0. 6439, 0. 6475, 0. 6305, 0. 6287, 0. 5907 and 0. 5825; and 6- PGDA gene frequencies w ere 0. 8881, 0. 9143, 0. 9330, 0. 9318, 0. 8756, 0. 9212, 0. 9188, 0. 9461 and 0. 9375, respectively. The EsD1 gene frequencies in Southern subpopulations o f the Han ethnic group in China a re quite different from those o f the Northern ones, which are higher than those of the Southern subpopulations, and lower gradually along with the decrease of latitude. The divergence of EsD and 6- PGD genes among Han subpopulations is quite significant while that of AcP gene not.

Key words: AcP1 , 6- PGD, EsD, Genetic polymorphism, Han