中国西藏拉托唐古墓地古代居民线粒体全基因组研究
收稿日期: 2019-02-26
修回日期: 2019-05-07
网络出版日期: 2021-02-25
基金资助
国家重点研发计划(2016YFE0203700);国家自然科学基金项目(41672021);国家自然科学基金项目(91731303);国家自然科学基金项目(41630102);中国科学院(QYZDB-SS W-DQC003);中国科学院(XDB26000000);中国科学院(XDB13040000)
A study of the mitochondrial genome of ancient inhabitants from the Latuotanggu cemetery, Tibet, China
Received date: 2019-02-26
Revised date: 2019-05-07
Online published: 2021-02-25
目前青藏高原高海拔地区古DNA研究匮乏。拉托唐古墓地位于青藏高原西南高海拔区域,本文对该墓地出土距今约700年的人骨进行古DNA提取,捕获了高质量线粒体全基因组数据,结合东亚线粒体基因组数据库,运用遗传统计方法开展分析。研究结果表明,距今3000年以内青藏高原西南部人群的遗传历史具有连续性,距今700年左右的拉托唐古墓地居民与距今3150-1250年的古代尼泊尔居民以及现代中国西藏居民母系遗传关系较近,且他们都具有共同的M9a1a1c1b1a单倍群。对M9a1a1c1b1a单倍群的深入研究发现,距今10930-5150年期间青藏高原可能发生了人口扩张事件。以上结果为我们了解古代青藏高原高海拔地区人群遗传历史提供了重要信息。
丁曼雨 , 何伟 , 王恬怡 , 夏格旺堆 , 张明 , 曹鹏 , 刘峰 , 戴情燕 , 付巧妹 . 中国西藏拉托唐古墓地古代居民线粒体全基因组研究[J]. 人类学学报, 2021 , 40(01) : 1 -11 . DOI: 10.16359/j.cnki.cn11-1963/q.2020.0078
With rapid advances in next generation sequencing technologies, we have extracted three ancient DNA from samples from Tibet. With a dataset of present-day East Asians, we tried to reconstruct the history of this region using population genetic methods. Using the mtDNA genome, our study focused on the maternal relationship between ancient Tibetans living in 700BP and present-day populations, which revealed a genetic continuity on Tibetan plateau between the LaTuoTangGu (LTTG) cemetery and present-day Tibetans. This study is the first mtDNA genomic research of high elevation Tibetans.
Key words： Tibet; Ancient DNA; Mitochondrial genome; Latuotanggu; Neolithic
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