遗传和环境因素对儿童青少年身体高度及其比例的影响
收稿日期: 2020-09-05
修回日期: 2021-07-26
网络出版日期: 2022-10-13
基金资助
国家自然科学基金项目(30960167);国家自然科学基金项目(31260265);内蒙古自治区自然科学基金项目(2019MS08166)
Effects of genetic and environmental factors on body height and proportion of children and adolescents
Received date: 2020-09-05
Revised date: 2021-07-26
Online published: 2022-10-13
目前有关儿童青少年坐高、下肢长及其比值的报道多为非双生子人群的研究。为了解遗传和环境因素对儿童青少年坐高、下肢长及坐高与下肢长比值影响的相对大小,我们对796对6~18岁双生子的身高和坐高进行了测量,计算下肢长及坐高与下肢长比值,采用结构方程模型分析其遗传和环境相对效应。结果发现,校正年龄后,男女15~18岁年龄组坐高和下肢长的遗传度(0.63~0.78)均分别高于同性别低年龄段儿童青少年(0.31~0.68);坐高与下肢长比值的遗传度除9~11岁女生(0.84)外,其他年龄组均较低(男0.16~0.46,女0.21~0.57);共同环境因素和特殊环境因素对6~14岁儿童青少年各指标的作用较大。本研究提示,在快速发育时期,坐高、下肢长和坐高与下肢长比值对环境因素更为敏感,遗传度较低;机体越成熟,其遗传效应更强。
刘燕 , 李玉玲 . 遗传和环境因素对儿童青少年身体高度及其比例的影响[J]. 人类学学报, 2022 , 41(05) : 875 -882 . DOI: 10.16359/j.1000-3193/AAS.2021.0079
Most of the studies on sitting height(h), lower limb length(L), and their ratio(h/L) were based on non-twin populations. To understand the relative influence of genetic and environmental factors on the sitting height, lower limb length and the ratio of sitting height to lower limb length of children and adolescents, we measured their standing height(H) and sitting height of 796 pairs of twins aged 6-18 years old, and computed their lower limb length and the ratio of h and L. Genetic analyses was done using structural equation models. After adjusting the age, the degree of heritability(d) of h and L in the 15-18 years old group(0.63≤d<0.78) was higher than that for h and L in other younger age groups(0.31≤d<0.68) in both sexes; the heritability of h/L in boys(0.16≤d<0.46) and girls (0.21≤d<0.57) was low except for that of h/L in girls (d=0.84) aged 9-11 years. Our study findings show that common and unique environmental factors exerted a stronger influence on these anthropometric measurements in children and adolescents aged 6-14 years, suggesting during the period of rapid growth, their h, L and h/L are more sensitive to environmental effects. When individuals approached maturity, the genetic effects became stronger.
Key words: Body proportions; Development; Twins; Heritability
[1] | Xi H, Chen Z, Li W, et al. Chest circumference and sitting height among children and adolescents from Lhasa, Tibet compared to other high altitude populations[J]. American Journal of Human Biology, 2016, 28(2): 197-202 |
[2] | Zhu M, Jiao YH, Xiong F, et al. Analysis of limb segments length and body proportion of southern Chinese children and adolescents[J]. Journal of Paediatrics and Child Health, 2015, 51(12): 1164-1171 |
[3] | Del Pino M, Ramos MR, Fano V. Leg length, sitting height, and body proportions references for achondroplasia: New tools for monitoring growth[J]. American Journal of Medical Genetics A, 2018, 176(4): 896-906 |
[4] | Merker A, Neumeyer L, Hertel NT, et al. Development of body proportions in achondroplasia: Sitting height, leg length, arm span, and foot length[J]. American Journal of Medical Genetics A, 2018, 176(9): 1819-1829 |
[5] | Zhang YQ, Li H. Reference charts of sitting height, leg length and body proportions for Chinese children aged 0-18 years[J]. Annals of Human Biology, 2015, 42(3): 223-230 |
[6] | Zhang YX, Zhao JS, Chu ZH. Percentiles of waist-to-sitting-height ratio and its relationship with obesity and elevated blood pressure among children and adolescents in Shandong, China[J]. Blood Pressure Monitoring, 2016, 21(1): 33-37 |
[7] | Bundak R, Bas F, Furman A, et al. Sitting height and sitting height/height ratio references for Turkish children[J]. European Journal of Pediatrics, 2014, 173(7): 861-869 |
[8] | Burton RF. Sitting height as a better predictor of body mass than total height and (body mass)/(sitting height) 3 as an index of build[J]. Annals of Human Biology, 2015, 42(3): 212-216 |
[9] | Ramoshaba NE, Monyeki KD, Mpya J, et al. The relationship between sitting height, sitting height to height ratio with blood pressure among Polokwane private school children aged 6-13 years[J]. Bmc Public Health, 2017, 17(1): 973-978 |
[10] | Rodríguez López S, Bensenor IM, Giatti L, et al. Association between maternal education and blood pressure: mediation evidence through height components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)[J]. Annals of Human Biology, 2017, 44(3): 243-251 |
[11] | Chang S, Ong HL, Abdin E, et al. Head circumference, leg length and its association with dementia among older adult population in Singapore[J]. International journal of geriatric psychiatry, 2017, 32(12): e1-e9 |
[12] | Said-Mohamed R, Prioreschi A, Nyati LH, et al. Rural-urban variations in age at menarche, adult height, leg-length and abdominal adiposity in black South African women in transitioning South Africa[J]. Annals of Human Biology, 2018, 45(2): 123-132 |
[13] | Prince MJ, Acosta D, Guerra M, et al. Leg length, skull circumference, and the incidence of dementia in Latin America and China: A 10/66 population-based cohort study[J]. PLOS ONE, 2018, 13(4): e0195133 |
[14] | He L, Pitkaniemi J, Silventoinen K, et al. ACEt: An R Package for Estimating Dynamic Heritability and Comparing Twin Models[J]. Behavior Genetics, 2017, 47(6): 620-641 |
[15] | 季成叶. 现代儿童少年卫生学(第2版)[M]. 北京: 人民卫生出版社, 2010 |
[16] | 席焕久, 陈昭. 人体测量方法[M]. 北京: 科学出版社, 2010 |
[17] | Neale MC, Boker SM, Xie G, et al. Mx:statistical modeling (6th edition)[M]. Richmond, VA:Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 2002 |
[18] | Dupae E, Defrise-Gussenhoven E, Susanne C. Genetic and Environmental Influences on Body Measurements of Belgian Twins[J]. ActaGeneticaeMedicaeetGemellologiae, 1982, 31(3-4): 139-144 |
[19] | Salces I, Rebato E, Susanne C, et al. Heritability variations of morphometric traits in West Bengal (India) children aged 4-19 years: A mixed-longitudinal growth study[J]. Annals of Human Biology, 2007, 34(2): 226-239 |
[20] | Sharma JC, SharmaK. Estimates of genetic variance for some selected morphometric characters: a twin study[J]. Acta Geneticae Medicae Et Gemellologiae, 1984, 33(3): 509-514 |
[21] | Arya R, Duggirala R, Comuzzie AG, et al. Heritability of Anthropometric Phenotypes in Caste Populations of Visakhapatnam, India[J]. Human Biology, 2002, 74(3): 325-344 |
[22] | Tanner JM, Cameron N. Investigation of the mid-growth in height, weight and limb circumferences in single-year velocity data from the London 1966-67 growth survey[J]. Annals of Human Biology, 1980, 7(6): 565-577 |
[23] | Sinclair D, Dangerfield P. Human growth after birth (6th edition)[M]. London: Oxford University Press, 2000 |
[24] | Iuliano-Burns S, Hopper J, Seeman E. The Age of Puberty Determines Sexual Dimorphism in Bone Structure: A Male/Female Co-Twin Control Study[J]. The Journal of Clinical Endocrinology and Metabolism, 2009, 94(5): 1638-1643 |
[25] | Zhang YX, Zhao JS, Chu ZH. Waist to sitting height ratio may be a new useful index for screening obesity and related health risk[J]. International journal of cardiology, 2015, 187(1): 126-127 |
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